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Plant Physiol 141: 685–701 [DOI] [PMC free article] [PubMed] [Google Scholar] Gilbert L, Alhagdow M, Nunes-Nesi A, Quemener B, Guillon F, Bouchet B, Faurobert M, Gouble B, Page D, Garcia V, et al
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In this setting, mitochondrial ROS from complex I/III sites, NOX2/NOX4 activity in microglia and cerebrovascular endothelium and impaired mitophagy (reduced removal of damaged mitochondria) converge to oxidize proteins and lipids, seed misfolding and aggregation (e.g., α-synuclein, Aβ) and blunt synaptic plasticity by altering redox-sensitive receptors, kinases and Ca²⁺ handling (Lee et al