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Curcumin significantly reduces the levels of pro-inflammatory cytokines involved in the onset and progression of ulcerative colitis, such as interleukin-1 alpha, interleukin-1 beta, interleukin-6, interleukin-8, interleukin-23, and tumor necrosis factor-alpha, among others (Sreedhar et al., 2016), and it also modulates inflammation by directly inhibiting key signaling pathways, including mitogen-activated protein kinase, nuclear factor kappa-B, and toll-like receptor 4 (Baliga et al., 2012)
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