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These metabolites activate AhR, upregulate Wnt pathway genes (Wnt3, β-catenin, Axin2), and expand the Lgr5 + ISC pool 55

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Simultaneously, ferroptosis may be involved in the progression of cardiac autonomic neuropathy (DCAN) through the P2Y14 receptor (a new member of the metabolic receptor family), while P2Y14 targeting naringin can alleviate DCAN by promoting the NRF2-GPX4 pathway to eliminate ROS and inhibit ferroptosis (117) ( Figure 2 )