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This pathway not only inactivates a key driver of copper toxicity but also reinforces a glycolytic phenotype that further diminishes mitochondrial susceptibility

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The C57BL/6 depilation model, the most commonly used mouse model in the field, measures hair regrowth after forced removal of all body hair, which creates a synchronized, uniform anagen response that does not accurately replicate the patchy, progressive follicle miniaturization of androgenetic alopecia or the diffuse shedding of telogen effluvium