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Moreover, the current review unifies typically siloed domains—CAA identity and signaling, substrate-level metabolic exchange, and immunometabolic control—into a single, testable framework that maps actionable nodes (e.g., LCN2, KRAS-linked programs, FAM3C) onto JAK/STAT3, PI3K/AKT/mTOR, HIF-1, and redox–lipid circuits