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BDNF plays an important role in the survival and growth of neurons and acts as a modulator of neurotransmission (Sadighparvar et al

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TNF-α also increase the the expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, which amplifies glutamatergic transmission and results in excessive calcium ion influx and neurotoxicity