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These challenges are actively under investigation and are well-documented in existing literature 66,67,68 , shedding light on the ongoing endeavors to optimize this delivery system for clinical translation in the treatment of various medical conditions, including RNA-based therapies for OA through local, rather than systemic, administration ( Box 1 )

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doi: 10.1016/j.chom.2018.10.001 214 YeşilyurtNYılmazBAğagündüzDCapassoR

95% of all carnitine stores in the body are found in muscle tissue