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Reactions were performed with 0.5 µM catechol substrate COMT-S01, 1 µM radiolabelled S-adenosyl-L-[methyl- 3 H] methionine (SAM) co-substrate, and recombinant human COMT enzyme

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Researchers have extensively investigated this peptide due to observations suggesting that this specific region of growth hormone may influence metabolic pathways distinct from those associated with full-length growth hormone activity