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Subsequent studies reveal that RIPK1 and RIPK3 (receptor interacting serine/threonine kinase 3) are key upstream kinases that initiate necroptosis through the phosphorylation of executor protein MLKL (mixed lineage kinase domain like pseudokinase) by multiple regulators [112]

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Thus, there is no correlation between multidrug resistant (MDR) phenotype and vulnerability to TP4