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Deletion of Cyp71b in mice ( Cyp7b1 −/− ) similarly reduces disease onset in the EAE model, which is accompanied by milder disease severity and an impaired infiltration of Th1 and Th17 CD4 + T cells (Song et al., 2024)

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Certain chemotherapeutic agents, including cytarabine and anthracycline, have been observed to potentially stimulate the formation of LAFs (81–83)