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In fact, there’s a high prevalence of low serum vitamin B12 among vegetarians, in particular vegans, where prevalence ranges at levels between 43% and 88%.6 Going back as far as 1955, studies have shown that vegans have experienced vitamin B12 deficiency.7 In addition, B12 crosses the placenta during pregnancy and is present in breast milk—thus, if the mother doesn’t receive adequate B12 intake, infants may suffer from B12 deficiency, which can lead to severe, permanent neurological damage.4 Norris says the story doesn’t end there
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A 2025 review by Zhang, Zhu, Sun, and colleagues in Archives of Biochemistry and Biophysics highlighted the growing interest in NNMT as a therapeutic target for non-alcoholic fatty liver disease, underscoring that pharmaceutical-grade NNMT inhibitors remain in the research pipeline rather than available as regulated medicines