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Intranasal delivery offers advantages such as rapid onset, ease of use, and good patient tolerance, especially for advanced patients who have difficulty swallowing oral drugs [60]

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Long-term complications are often multifactorial but commonly related to immunosuppressive drugs in use.86–88 Hepatocellular carcinoma Several population-based studies of AIP patients have shown an evidence of a significantly increased incidence of HCC in AIP compared to general population.14,15,89–91 The highest incidence of HCC (23%–27%, more than 60-fold increased risk compared to general population) was shown in the Finnish and Swedish patients with AIP.13,89,91 In contrast to renal insufficiency, HCC has developed in patients with both symptomatic and asymptomatic AIP, although the patients with manifested AIP are likely at higher risk