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Conversely, oxidative stress is attributed to unbridled production of ROS, surpassing the amount of antioxidant defenses and aggravating damage to cells, proteins, lipids and DNA, 18 a process which is also indicated by Fig

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4-HNE is involved in PD pathology by covalently modifying α-syn to promote its aggregation, disrupting the ubiquitin-proteasome system, and interfering with dopamine receptor function, and has been found to alter dopamine transport, contributing to dopamine loss (82, 86, 88)