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Many studies have identified a proximal AP-1 element (−263 to −269) to be critical in mediating the effect of oxidative stress-induced increase in human GCLC transcription (Morales et al., 1997

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Tamaño:50 gramos (1,8 onzas)

Once the glucuronide conjugation and sulfation pathways are saturated, excess acetaminophen is oxidized via the cytochrome P450 microsomal enzyme, resulting in the formation of NAPQI, a highly toxic metabolite [111]