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Although Tsvetkov P did not specify the roles of DLD, PDHA1 and PDHB in cuproptosis, the entire PDC, including DLD, PDHA1 and PDHB, tended to fail to function normally due to the complexity and close association of PDC as well as the inactivation of DLAT caused by oligomerization

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doi: 10.1073/pnas.0536856100 112