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Due to the involvement of the TCA cycle, the relationship between mitochondria and the cuproptosis pathway appears to be unquestionable, but researchers have different opinions on the role of mitochondria in ferroptosis

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In cultured human aortic endothelial cells, ebselen attenuated hydrogen peroxide-mediated upregulation of pro-inflammatory pathways that are associated with atherogenesis, such as the activation of NFkB and JNK signaling and the increased expression of TNF-α and NOX2 [81]