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Defects of mtDNA replication impaired mitochondrial biogenesis during Trypanosoma cruzi infection in human cardiomyocytes and chagasic patients: the role of Nrf1/2 and antioxidant response

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Although single binary markers of senescence commitment have long been used in preclinical research, their utility as clinical parameters have so far been limited due to the wide-ranging heterogeneity of senescence in vivo , which often renders estimates of senescent cell quantification imprecise