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doi: 10.1016/0090-4295(95)80019-0

PNB-0408

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thus, in 1980s, the opioid antagonist naloxone, which was approved for the treatment of opioid overdose by the FDA in 1971, was used in a double-blinded placebo-controlled clinical study to test its potential effect on improving cognitive functioning in individuals with probable AD (Reisberg et al., 1983)