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Stage-tips were activated with MeOH (2 × 60 μL), washed with Buffer B (80% CH 3 CN, 20% water, 0.1% formic acid) (1 × 60 μL), and equilibrated with Buffer A (2 × 60 μL)

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L-OHP further causes nuclear DNA damage, and its synergistic action significantly activates the STING pathway