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intramuscular vitamin B12 treatment) [7,8,9,10], four systematic reviews [11,12,13,14], six narrative reviews [5,15,16,17,18,19,20] and thirteen prospective studies fulfilled our inclusion criteria (Figure 1) [21,22,23,24,25,26,27,28,29,30,31,32,33,34]

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TABLE 2 Summary of morphine-, heroin-, nicotine-, and alcohol-induced neurotoxicity according to their effect on the structural integrity of the BBB and their respective molecular pathways