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[,] Mechanistically, acupuncture at Tai-Chong reduces endothelin-1 (ET-1) levels in the circulation and heart, [,] norepinephrine, epinephrine and renin levels in the circulation and kidney, β1-adrenergic receptor (β1-AR) levels in the kidney (but increased renal β2-AR levels), [] inhibits nicotinamide adenine dinucleotide phosphate oxidase-dependent oxidative stress in the rostral ventrolateral medulla (where sympathetic nervous control center is located)

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Acknowledgements The authors wish to express their gratitude to the support of Hong Kong SAR government GRF grant (Grant No

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