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In simple terms, the sequence usually looks like this: Protein → Purines → Uric Acid → Reduced excretion → Crystal deposition in joints When these uric acid crystals deposit inside the joint, the body mounts a strong inflammatory response and that is what produces the intense pain many patients describe
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Nucleation comprises the response of autophagy-specific VPS34 complex I (including VPS34, beclin-1, ATG14, and VPS15) to the ULK complex, thereby catalyzing phosphatidylinositol-3-phosphate (PI3P) production on the autophagosome membrane
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