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consequently, its discussion has been trimmed and moved to Future Directions, explicitly acknowledging the absence of clinical evidence and the PK uncertainties (dose, timing, BBB penetration, and formulation effects) relevant to rapid ascent scenarios

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In the case of deficiency of these enzymes (due to gene polymorphisms, or acquired by events such as viral infections, as in HIV infection), these accumulated arene-oxide intermediates act as haptens, stimulating the immune response or binding to tissue macromolecules and causing direct cell damage