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Ein anschauliches Beispiel liefert das zugelassene orale Semaglutid (Rybelsus): Trotz aufwendiger Formulierungstechnologie liegt seine absolute orale Bioverfügbarkeit bei nur etwa 1 % (Buckley et al., 2018)

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Recently, an emerging approach to inhibit overactive or overexpressed proteins is to develop proteolysis-targeting chimeras (PROTACs) that can efficiently degrade the targeted protein of interest (POI) by hijacking the ubiquitin-proteasome system 33,34