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The excitatory amino acid glutamate (Glu) is taken up by the Na + -dependent excitatory amino acid transporter-1 (EAAT1 or GLAST) and EAAT2 (GLT-1) and converted to glutamine (Gln) by the astrocyte-specific enzyme glutamine synthetase (GS) (Figure 1.3 and 2.10)

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