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4 The recommendations are based on the association between the DPYD genotype and DPD enzyme activity, therapeutic drug monitoring (5-FU pharmacokinetics), and severe fluoropyrimidine-associated toxicity
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The National Institutes of Health Office of Dietary Supplements notes that “vitamin B12 is a nutrient that helps keep the body’s nerve and blood cells healthy and helps make DNA, the genetic material in all cells.” When levels are low, you might notice: Fatigue that sleep doesn’t fully fix Slower recovery from training Trouble focusing or remembering details Numbness, tingling, or “pins and needles” Pale skin, shortness of breath, or lightheadedness If you have risk factors, vegan/vegetarian diet, heavy training, frequent alcohol use, long-term acid-reducing meds, GI issues, or simply getting older, then getting B12 delivery right matters for day-to-day performance and long-term health
