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Platelet activation and platelet–leukocyte interaction in β-thalassemia/hemoglobin E patients with marked nucleated erythrocytosis

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When the body is exposed to stress, the paraventricular nucleus (PVN) of the hypothalamus secretes corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP), which stimulate the anterior pituitary to release adrenocorticotropic hormone (ACTH) (Heim et al., 2000