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Longitudinal studies in animal models and post-mortem human tissues are needed to determine whether microglial iron overload is a cause or consequence of α-syn pathology, and to identify the disease stage at which glial modulation is most therapeutically beneficial

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CM-10 has a positive effect when ligated to scaffolds, so perhaps this is the optimal manner in which to use these peptides as free peptides may actually be unstable and easy diluted in vivo