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20.4% (treatment policy estimand) Semaglutide alone (GLP-1S): 16.1% / 14.9% Cagrilintide alone (GLP-1C): 11.8% / 11.5% Placebo: 2.3% / 3.0% ≥5% weight loss achieved: 91.9% of CagriSema participants vs 31.5% placebo ≥25% weight loss achieved: 40.4% of CagriSema participants vs 16.2% semaglutide alone REDEFINE 2 Trial (NEJM, June 2025) — Type 2 Diabetes Population: CagriSema achieved 13.7% weight reduction vs 3.1% placebo at 68 weeks in adults with obesity and T2D These results confirm that the GLP-1C + GLP-1S combination — engaging both the amylin/calcitonin axis and the GLP-1 incretin axis simultaneously — delivers outcomes that are clearly supra-additive relative to either compound in isolation
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