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The active form, 1,25-dihydroxyvitamin D3 (1,25[OH] 2 D 3 ), binds to the vitamin D receptor (VDR) expressed in endometrial stromal cells, leading to suppression of pro-inflammatory cytokine production (e.g., IL-8, TNF-α), inhibition of NF-κB signaling, and reduction in prostaglandin synthesis, which collectively dampen the chronic inflammatory milieu characteristic of endometriosis [20,21,22,23]

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Nature 519 (7544), S19