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59 Further investigations revealed that epigenetic reprogramming in various immune cells, such as polymorphonuclear myeloid-derived suppressor cells (MDSCs), the major infiltrating immune cell type that causes immune evasion in prostate cancer, contributes to an immunosuppressive microenvironment

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In the Peyer patches, enterocytes overlying lymphoid aggregates are modified into follicle epithelium and M cells, probably in response to signals from underlying lymphoid cells