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Accordingly, a plethora of studies conducted in different animal model of CNS disorders showed that the assumption of probiotics increased intestinal tight junctions’ expression, restored colonic mucus cells loss, that, in turn, can reduce immune/inflammatory responses and alleviate central symptoms (Pellegrini et al., 2023)

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These results suggest that mTiO 2 can stimulate BMMC activation at high concentrations (≥25 µg/mL)