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Conversely, restoration of NAD + to aged animals, by either augmenting biosynthesis or inhibiting consumption, promotes health, improves performance (including mitochondrial function), and extends lifespan in animal experiments.[43–50] These types of studies suggest that the daily value amount might not be sufficient to optimize cellular performance (especially as we age)

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Proton pump inhibitors and diuretics can impair absorption of nutrients required for glutathione synthesis, including magnesium and B vitamins