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As for multifactorial therapies, like platelet - rich plasma (PRP) or exosomes, several challenges exist, including high costs, the risk of immune reactions from allogeneic injections, and difficulties in ensuring the homogeneity of the therapy
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Among these, inflammatory conditions, such as IBD, and functional bowel disorders, such as IBS, are both characterized by a well-established microbiota dysbiosis associated with impairment of intestinal permeability