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In vitro transdermal experiments showed that the cumulative transdermal amount of MXS-LPSs at 36 h was 225.98 ± 11.53 μg·cm −2 , which was lower than that of the MXS aqueous solution, but the proportion of drug deposition in the skin beneath the stratum corneum reached 59.80 ± 26.27%, significantly higher than that of the MXS solution (32.55 ± 1.61%) and minoxidil solution (43.18 ± 6.58%)