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Therefore, coordination between autophagy and the ubiquitin–proteasome system (UPS) is necessary to promote the degradation of GPX4

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Thanks to the positive charge, it also creates a complex with AHAs (AHAs like to lose a hydrogen ion and be negatively charged, so the positive and the negative ions attract each other) that causes a "time-release AHA effect" and reduces the irritation associated with AHAs