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Our team has observed that for studies focusing on long-term, sustained NNMT inhibition where slight variations in peak plasma concentration aren't catastrophic, the oral route might be sufficient
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Historically, this increased insulin response mediated by GLP-1 and GIP had been attributed to factors termed “incretins” (derived from “incretion”, a term used at that time to refer to a secretion that remains inside the body), hence the name “incretin effect” is still used today to describe the rise in insulin mediated by the action of these hormones
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