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Also, hyperprolactinemia can have some pathological causes, such as the following: Hypothyroidism Pituitary adenomas (prolactinomas) Chronic renal failure Polycystic ovary syndrome (PCOS) Hyperandrogenism Anorexia nervosa Stress and anxiety Multiple Sclerosis Cancer and pituitary tumors There is also a type of iatrogenic hyperprolactinemia , caused by external factors such as neuroleptic drugs, antidepressants, anxiolytics, tranquilizers, opioids (morphine derivatives), and so on