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showed that incubation of endothelial progenitor cells with the serum of T2DM patients inhibits their migration toward bFGF, increases their expression of VEGFR-2, but reduces their expression of VEGFR-1 and induces their apoptosis (59)

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In line with this assumption, for all three viruses, we observed a highly significant enrichment of known physical interaction partners of the viral proteome among predicted tier-1 targets compared to tier-2 targets and all other enzymes (Fig