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In severe AH, upregulation of YAP, downregulation of ESRP2, and differential splicing of the nuclear receptor HNF4α results in aberrant upregulation of periportal hepatocyte genes, hepatocyte fetal reprogramming, and activation of the ductular reaction, where periportal hepatocytes and liver progenitor cells activate and become either mature hepatocytes or cholangiocytes (67, 90, 91)

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2014;99:E1798–1802