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10.1016/j.ejogrb.2017.08.019 10

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These alterations are not likely a consequence of altered binding affinity, as in vitro studies demonstrated that the N40D substitution did not affect binding of the exogenous opioids morphine, fentanyl, or methadone, nor that of the endogenous opioids Met- and Leu-enkephalin, endomorphin-1 and-2 and d-Ala 2 , N -methyl-Phe 4 , Glycol 5 ]enkephalin (DAMGO) (54)