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Nevertheless, it is important to note that the aforementioned study had various limitations besides its retrospective nature, such as the lack of information regarding the semaglutide and tirzepatide titration schedule used and the side effects experienced by patients [136]

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Across contemporary scientific discussions, mucosal delivery variants of HGH-97 versus traditional subcutaneous administration methods consistently surface in exploratory framework evaluations regarding direct nose-to-brain transport efficiency, absorption pharmacokinetics, and mucosal barrier tolerance, with researchers actively tracking localized nasal passage irritation, mild mucosal dryness, or variable bioavailability coefficients