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These include antidepressants such as duloxetine and milnacipran (serotonin–norepinephrine reuptake inhibitors), tricyclic antidepressants such as amitriptyline, central nervous system depressants such as zolpidem, voltage-gated Ca² + channel inhibitors including pregabalin and gabapentin, muscle relaxants such as cyclobenzaprine orally disintegrating tablets, and opioid analgesics such as tramadol and oxycodone