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Network biology implemented computational models to interpret gene regulatory networks (GRNs) (289), protein-protein interaction (PPI) networks (290) and signaling cascades (291), characterizing the key modules, hubs, and bottlenecks linked with cancer phenotypes

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Furthermore, the kynurenine/tryptophan ratio was markedly diminished in the tumors from the JHU083-treated mice (Figure 11E)