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10.1016/j.biopha.2016.10.011 178 SunG

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From mechanistic pathways to targeted interventions: mitochondria and RCD-directed therapy Based on the aforementioned mechanisms, mitochondria and RCD-directed therapy can target different pathological nodes: mitochondria-targeted antioxidants primarily address mtROS accumulation, MQC regulation focuses on mitochondrial renewal and damage clearance, and RCD intervention targets downstream inflammatory or oxidative cell death (212)