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Particularly noteworthy is that FOXO4 influences not only lifespan but also the quality of aging through its interaction with the protein p53—commonly referred to as the "guardian of the genome." This interaction regulates whether cells remain in a senescent, metabolically inactive state or undergo programmed cell death (apoptosis)

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It is isolated from a peptide complex called epithalamin, itself derived from bovine pineal glands, and primarily acts within the neuroendocrine system [1, 2]

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