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26 Biochemical abnormalities commonly seen in patients with ASD include impaired methylation, sulphation capacities and low glutathione (GSH) redox capacity, all of which can potentially respond to B12 supplementation

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The key finding of an activated particular collateral pathway, i.e., the azygos vein, which combined the inferior caval vein and left superior vein to reorganize blood flow, might be responsible for the noted beneficial effects