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However, it's important to note that Sermorelin is only effective when the pituitary gland retains functional capacity to produce GH - in cases of severe pituitary damage, tumor, or congenital absence of somatotrophs, direct GH replacement would be required as Sermorelin would have no tissue to stimulate

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Additionally, this combined regimen significantly accelerates the rate of decline in serum alpha-fetoprotein (AFP) levels (Cao et al., 2016)