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(4) adipocyte-specific depletion of p53 impedes excessive macrophage abundance under IF and (5) improves the systemic response to fasting, as evident by an increased catabolic state of adipocytes, accelerated body weight loss, improved systemic insulin sensitivity, and enhanced metabolic flexibility of adipocytes

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VEGFR1 tyrosine kinase signaling promotes lymphangiogenesis as well as angiogenesis indirectly via macrophage recruitment