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however, at protein level, the amounts of IGF-1, IGF-2 and TNF-α in the skeletal muscle of hemodialysis patients were found elevated in comparison to the control group,139 which may suggest impaired IGF-1 signaling activation as observed in animal models of renal insufficiency,137 considering the decreased muscle strength in the hemodialysis group

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The effect of MGBA arises primarily through neuroinflammatory pathways, microbial metabolites, and the modulation of systemic immune responses, influencing the brain pathology (Mulak, 2021